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1

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5

Johannes Lemke, Andreas Noack, Dieter Adam, Vladimir Tchikov, Uwe Bertsch, Christian Röder, Stefan Schütze, Harald Wajant, Holger Kalthoff, Anna Trauzold

Journal:

Journal of Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 463 KB

english, 2010

2

Multimodal Bioactivation of Hydrophilic Electrospun Nanofibers Enables Simultaneous Tuning of Cell Adhesivity and Immunomodulatory Effects

Wistlich, Laura, Kums, Juliane, Rossi, Angela, Heffels, Karl-Heinz, Wajant, Harald, Groll, Jürgen

Journal:

Advanced Functional Materials

Year:

2017

Language:

english

File:

PDF, 1.97 MB

english, 2017

3

Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

Matthias Grell, Florian M. Becke, Harald Wajant, Daniela N. Männel, Peter Scheurich

Journal:

European Journal of Immunology

Year:

1998

Language:

english

File:

PDF, 112 KB

english, 1998

4

TWEAK can induce cell death via endogenous TNF and TNF receptor 1

Pascal Schneider, Ralph Schwenzer, Elvira Haas, Frank Mühlenbeck, Gisela Schubert, Peter Scheurich, Jürg Tschopp, Harald Wajant

Journal:

European Journal of Immunology

Year:

1999

Language:

english

File:

PDF, 186 KB

english, 1999

5

Über die erste rekombinante Hydroxynitril-Lyase und ihre Anwendung in der Synthese von (S)-Cyanhydrinen

Dr. Siegfried Förster, Jürgen Roos, Prof. Franz Effenberger, Dr. Harald Wajant, Achim Sprauer

Journal:

Angewandte Chemie

Year:

1996

Language:

german

File:

PDF, 286 KB

german, 1996

6

The First Recombinant Hydroxynitrile Lyase and its Application in the Synthesis of (S)-Cyanohydrins

Dr. Siegfried Förster, Dipl.-Chem. Jürgen Roos, Prof. Franz Effenberger, Dr. Harald Wajant, Dipl.-Ing.(FH) Achim Sprauer

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 409 KB

english, 1996

7

Substrate Specificity of Mutants of the Hydroxynitrile Lyase from Manihot esculenta

Holger Bühler, Franz Effenberger, Siegfried Förster, Jürgen Roos, Harald Wajant

Journal:

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

8

Enhanced basal AP-1 activity and de-regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1

Svetla Chaneva, Günter Schneider, Daniela Siegmund, Harald Wajant, Jörg Mages, Georg Häcker

Journal:

European Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

9

Selective elimination of pathogenic synovial fluid T-cells from Rheumatoid Arthritis and Juvenile Idiopathic Arthritis by targeted activation of Fas-apoptotic signaling

Edwin Bremer, Wayel H. Abdulahad, Marco de Bruyn, Douwe F. Samplonius, Cees G.M. Kallenberg, Wineke Armbrust, E. Brouwers, Harald Wajant, Wijnand Helfrich

Journal:

Immunology Letters

Year:

2011

Language:

english

File:

PDF, 514 KB

english, 2011

10

Hydroxynitrile lyases in stereoselective catalysis

Franz Effenberger, Siegfried Förster, Harald Wajant

Journal:

Current Opinion in Biotechnology

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

11

Characterization and synthetic applications of recombinant AtNIT1 from Arabidopsis thaliana

Steffen Osswald, Harald Wajant, Franz Effenberger

Journal:

Year:

2002

Language:

english

File:

PDF, 273 KB

english, 2002

12

Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4)

Heike Glauner, Daniela Siegmund, Hassan Motejadded, Peter Scheurich, Frank Henkler, Ottmar Janssen, Harald Wajant

Journal:

Year:

2002

Language:

english

File:

PDF, 778 KB

english, 2002

13

Molecular cloning of hydroxynitrile lyase fromSorghum bicolor(L.). Homologies to serine carboxypeptidases

Harald Wajant, Karl-Wolfgang Mundry, Klaus Pfizenmaier

Journal:

Plant Molecular Biology

Year:

1994

Language:

english

File:

PDF, 1.17 MB

english, 1994

14

Identification of a TRAF (TNF Receptor-Associated Factor) Gene inCaenorhabditis elegans

Harald Wajant, Frank Mühlenbeck, Peter Scheurich

Journal:

Journal of Molecular Evolution

Year:

1998

Language:

english

File:

PDF, 972 KB

english, 1998

15

A CD40–CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95

Constance Assohou-Luty, Jeanette Gerspach, Daniela Siegmund, Nicole Müller, Bertrand Huard, Gisa Tiegs, Klaus Pfizenmaier, Harald Wajant

Journal:

Journal of Molecular Medicine

Year:

2006

Language:

english

File:

PDF, 1.15 MB

english, 2006

16

Erratum to: TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5

Johannes Lemke, Andreas Noack, Dieter Adam, Vladimir Tchikov, Uwe Bertsch, Christian Röder, Stefan Schütze, Harald Wajant, Holger Kalthoff, Anna Trauzold

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 55 KB

english, 2011

17

Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface

Jeannette Gerspach, Julia Németh, Sabine Münkel, Harald Wajant, Klaus Pfizenmaier

Journal:

Cancer Immunology, Immunotherapy

Year:

2006

Language:

english

File:

PDF, 485 KB

english, 2006

18

Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values

Jan von Langermann, Jan-Karl Guterl, Martina Pohl, Harald Wajant, Udo Kragl

Journal:

Bioprocess and Biosystems Engineering

Year:

2008

Language:

english

File:

PDF, 293 KB

english, 2008

19

Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization

Nicole Müller, Agnes Wyzgol, Sabine Münkel, Klaus Pfizenmaier, Harald Wajant

Journal:

Year:

2008

Language:

english

File:

PDF, 326 KB

english, 2008

20

Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways

Daniela Berg, Thorsten Stühmer, Daniela Siegmund, Nicole Müller, Tina Giner, Oliver Dittrich-Breiholz, Michael Kracht, Ralf Bargou, Harald Wajant

Journal:

Year:

2009

Language:

english

File:

PDF, 818 KB

english, 2009

21

TNFR1-induced activation of the classical NF-κB pathway

Harald Wajant, Peter Scheurich

Journal:

Year:

2011

Language:

english

File:

PDF, 444 KB

english, 2011

22

Increasing complexity in TNFR1 signaling

Journal:

Year:

2011

Language:

english

File:

PDF, 46 KB

english, 2011

23

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

Engels, Ingo H, Stepczynska, Ania, Stroh, Christopher, Lauber, Kirsten, Berg, Christoph, Schwenzer, Ralf, Wajant, Harald, Jänicke, Reiner U, Porter, Alan G, Belka, Claus

Journal:

Year:

2000

Language:

english

File:

PDF, 327 KB

english, 2000

24

p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

Bartke, Till, Siegmund, Daniela, Peters, Nathalie, Reichwein, Monica, Henkler, Frank, Scheurich, Peter, Wajant, Harald

Journal:

Year:

2001

Language:

english

File:

PDF, 344 KB

english, 2001

25

Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative

Wajant, Harald, Moosmayer, Dieter, Wüest, Thomas, Bartke, Till, Gerlach, Elke, Schönherr, Ulrike, Peters, Nathalie, Scheurich, Peter, Pfizenmaier, Klaus

Journal:

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

26

Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta

Hanspeter Lauble, Burkhard Miehlich, Siegfried Förster, Christoph Kobler, Harald Wajant, Franz Effenberger

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 468 KB

english, 2002

27

Improving TNF as a cancer therapeutic: Tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects

Jeannette Gerspach, Klaus Pfizenmaier, Harald Wajant

Journal:

Year:

2009

Language:

english

File:

PDF, 527 KB

english, 2009

28

Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells

Daniela Siegmund, Stefanie Klose, Donghui Zhou, Bernd Baumann, Christian Röder, Holger Kalthoff, Harald Wajant, Anna Trauzold

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 1.94 MB

english, 2007

29

The TNF-receptor-associated factor family: Scaffold molecules for cytokine receptors, kinases and their regulators

Harald Wajant, Frank Henkler, Peter Scheurich

Journal:

Cellular Signalling

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

30

Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction

Harald Wajant, Franz-Josef Johannes, Elvira Haas, Katrin Siemienski, Ralph Schwenzer, Gisela Schubert, Tilo Weiss, Matthias Grell, Peter Scheurich

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 132 KB

english, 1998

31

Protein kinase Cμ downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-κB-dependent protective genes

Franz-Josef Johannes, Judith Horn, Gisela Link, Elvira Haas, Katrin Siemienski, Harald Wajant, Klaus Pfizenmaier

Journal:

Year:

1998

Language:

english

File:

PDF, 402 KB

english, 1998

32

Cloning of a cDNA encoding a new ribosome-inactivating protein from Beta vulgaris vulgaris (mangold)

Ellen Hornung, Harald Wajant, Holger Jeske, Karl-Wolfgang Mundry

Journal:

Year:

1996

Language:

english

File:

PDF, 427 KB

english, 1996

33

Interferons induce proteolytic degradation of TRAILR4

Andreas Wicovsky, Daniela Siegmund, Harald Wajant

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 326 KB

english, 2005

34

Superior serum half life of albumin tagged TNF ligands

Nicole Müller, Britta Schneider, Klaus Pfizenmaier, Harald Wajant

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

35

The CD95 Receptor: Apoptosis Revisited

Marcus E. Peter, Ralph C. Budd, Julie Desbarats, Stephen M. Hedrick, Anne-Odile Hueber, M. Karen Newell, Laurie B. Owen, Richard M. Pope, Juerg Tschopp, Harald Wajant, David Wallach, Robert H. Wiltrou

Journal:

Year:

2007

Language:

english

File:

PDF, 97 KB

english, 2007

36

Tumor therapeutics by design: targeting and activation of death receptors

Harald Wajant, Jeannette Gerspach, Klaus Pfizenmaier

Journal:

Cytokine & Growth Factor Reviews

Year:

2005

Language:

english

File:

PDF, 476 KB

english, 2005

37

Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis

Martin Irmler, Véronique Steiner, Curzio Ruegg, Harald Wajant, Jürg Tschopp

Journal:

Year:

2000

Language:

english

File:

PDF, 291 KB

english, 2000

38

Purification and characterization of hydroxynitrile lyase from Hevea brasiliensis

Harald Wajant, Siegfried Förster

Journal:

Year:

1996

Language:

english

File:

PDF, 605 KB

english, 1996

39

Expression of the Zn2+-containing hydroxynitrile lyase from flax (Linum usitatissimum) in Pichia pastoris— utilization of the recombinant enzyme for enzymatic analysis and site-directed mutagenesis

Klaus Trummler, Jürgen Roos, Ulrich Schwaneberg, Franz Effenberger, Siegfried Förster, Klaus Pfizenmaier, Harald Wajant

Journal:

Year:

1998

Language:

english

File:

PDF, 184 KB

english, 1998

40

Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33–34

Katrin Siemienski, Nathalie Peters, Peter Scheurich, Harald Wajant

Journal:

Year:

1997

Language:

english

File:

PDF, 342 KB

english, 1997

41

Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling

Harald Wajant, Peter Scheurich

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2001

Language:

english

File:

PDF, 319 KB

english, 2001

42

Non-apoptotic Fas signaling

Harald Wajant, Klaus Pfizenmaier, Peter Scheurich

Journal:

Cytokine & Growth Factor Reviews

Year:

2003

Language:

english

File:

PDF, 275 KB

english, 2003

43

Tumor necrosis factors in 1996

Klaus Pfizenmaier, Harald Wajant, Matthias Grell

Journal:

Cytokine & Growth Factor Reviews

Year:

1996

Language:

english

File:

PDF, 785 KB

english, 1996

44

Engineering death receptor ligands for cancer therapy

Wajant, Harald, Gerspach, Jeannette, Pfizenmaier, Klaus

Journal:

Year:

2013

Language:

english

File:

PDF, 901 KB

english, 2013

45

Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development

Anette Preiss, Bernd Johannes, Anja C. Nagel, Dieter Maier, Nathalie Peters, Harald Wajant

Journal:

Mechanisms of Development

Year:

2001

Language:

english

File:

PDF, 642 KB

english, 2001

46

Hydroxynitrile lyase from Sorghum bicolor: a glycoprotein heterotetramer

Harald Wajant, Karl-Wolfgang Mundry

Journal:

Year:

1993

Language:

english

File:

PDF, 931 KB

english, 1993

47

Immunocytological localization of hydroxynitrile lyases from Sorghum bicolor L. and Linum usitatissimum L.

Harald Wajant, Dietmar Riedel, Sabine Benz, Karl-Wolfgang Mundry

Journal:

Year:

1994

Language:

english

File:

PDF, 1.62 MB

english, 1994

48

Acetone cyanohydrin lyase from Manihot esculenta (cassava) is serologically distinct from other hydroxynitrile lyases

Harald Wajant, Siegfried Förster, Heiner Böttinger, Franz Effenberger, Klaus Pfizenmaier

Journal:

Year:

1995

Language:

english

File:

PDF, 946 KB

english, 1995

49

Integrin-linked kinase is dispensable for multiple myeloma cell survival

Torsten Steinbrunn, Daniela Siegmund, Mindaugas Andrulis, Evelyn Grella, Martin Kortüm, Hermann Einsele, Harald Wajant, Ralf C. Bargou, Thorsten Stühmer

Journal:

Leukemia Research

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

50

Implication of TNF-Related Apoptosis-Inducing Ligand in Inflammatory Intestinal Epithelial Lesions

Bernadette Begue, Harald Wajant, Jean–Christophe Bambou, Laurent Dubuquoy, Daniela Siegmund, Jean–François Beaulieu, Danielle Canioni, Dominique Berrebi, Nicole Brousse, Pierre Desreumaux, Jacques Sch

Journal:

Gastroenterology

Year:

2006

Language:

english

File:

PDF, 1024 KB

english, 2006

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